Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies

Circulating immune complexes (CICs) isolated from sera of patients with IgA nephropathy (IgAN) consist of undergalactosylated, mostly polymeric, and J chain–containing IgA1 and IgG antibodies specific for N-acetylgalactosamine (GalNAc) residues in O-linked glycans of the hinge region of IgA1 heavy c...

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Main Authors: Tomana, Milan, Novak, Jan, Julian, Bruce A., Matousovic, Karel, Konecny, Karel, Mestecky, Jiri
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1999
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC408399/
https://ncbi.nlm.nih.gov/pubmed/10393701
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