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Lymphopenia associated with highly virulent H5N1 virus infection due to plasmacytoid dendritic cell mediated apoptosis of T cells

Although lymphopenia is a hallmark of severe infection with highly pathogenic H5N1 and the newly emerged H7N9 influenza viruses in humans, the mechanism(s) by which lethal H5N1 viruses cause lymphopenia in mammalian hosts remains poorly understood. Because influenza-specific T cell responses are ini...

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Detalhes bibliográficos
Main Authors: Boonnak, Kobporn, Vogel, Leatrice, Feldmann, Friederike, Feldmann, Heinz, Legge, Kevin L., Subbarao, Kanta
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083746/
https://ncbi.nlm.nih.gov/pubmed/24829418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302992
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