Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle

Hematopoietic stem cells (HSCs) maintain homeostasis and regenerate the blood system throughout life. It has been postulated that HSCs may be uniquely capable of preserving their genomic integrity to ensure lifelong function. To directly test this, we quantified DNA damage in HSCs and downstream pro...

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Detaylı Bibliyografya
Asıl Yazarlar: Beerman, Isabel, Seita, Jun, Inlay, Matthew A, Weissman, Irving L., Rossi, Derrick J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082747/
https://ncbi.nlm.nih.gov/pubmed/24813857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.04.016
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