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Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle
Hematopoietic stem cells (HSCs) maintain homeostasis and regenerate the blood system throughout life. It has been postulated that HSCs may be uniquely capable of preserving their genomic integrity to ensure lifelong function. To directly test this, we quantified DNA damage in HSCs and downstream pro...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4082747/ https://ncbi.nlm.nih.gov/pubmed/24813857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.04.016 |
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