The cyclin dependent kinase inhibitor (R)-roscovitine mediates selective suppression of alloreactive human T cells but preserves pathogen-specific and leukemia-specific effectors

Graft versus host disease (GvHD), mediated by donor T cells, remains the primary cause of non-relapse mortality after allogeneic hematopoietic stem cell transplantation and novel therapeutic approaches are required. Cdk2 is a critical node of signal integration and programming of T cell responses to...

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Bibliographic Details
Main Authors: Nellore, Anoma, Liu, Bianling, Patsoukis, Nikolaos, Boussiotis, Vassiliki A., Li, Lequn
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082337/
https://ncbi.nlm.nih.gov/pubmed/24631965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2014.02.015
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