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Structural-Functional Analysis of the Third Transmembrane Domain of the Corticotropin-releasing Factor Type 1 Receptor: ROLE IN ACTIVATION AND ALLOSTERIC ANTAGONISM

The corticotropin-releasing factor (CRF) type 1 receptor (CRF(1)R) for the 41-amino acid peptide CRF is a class B G protein-coupled receptor, which plays a key role in the response of our body to stressful stimuli and the maintenance of homeostasis by regulating neural and endocrine functions. CRF a...

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Bibliografiska uppgifter
Huvudupphovsmän: Spyridaki, Katerina, Matsoukas, Minos-Timotheos, Cordomi, Arnau, Gkountelias, Kostas, Papadokostaki, Maria, Mavromoustakos, Thomas, Logothetis, Diomedes E., Margioris, Andrew N., Pardo, Leonardo, Liapakis, George
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081936/
https://ncbi.nlm.nih.gov/pubmed/24838244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544460
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