Structure of the Trehalose-6-phosphate Phosphatase from Brugia malayi Reveals Key Design Principles for Anthelmintic Drugs

Parasitic nematodes are responsible for devastating illnesses that plague many of the world's poorest populations indigenous to the tropical areas of developing nations. Among these diseases is lymphatic filariasis, a major cause of permanent and long-term disability. Proteins essential to nema...

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Hlavní autoři: Farelli, Jeremiah D., Galvin, Brendan D., Li, Zhiru, Liu, Chunliang, Aono, Miyuki, Garland, Megan, Hallett, Olivia E., Causey, Thomas B., Ali-Reynolds, Alana, Saltzberg, Daniel J., Carlow, Clotilde K. S., Dunaway-Mariano, Debra, Allen, Karen N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081830/
https://ncbi.nlm.nih.gov/pubmed/24992307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004245
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