Cationic Lipid-Formulated DNA Vaccine against Hepatitis B Virus: Immunogenicity of MIDGE-Th1 Vectors Encoding Small and Large Surface Antigen in Comparison to a Licensed Protein Vaccine

Currently marketed vaccines against hepatitis B virus (HBV) based on the small (S) hepatitis B surface antigen (HBsAg) fail to induce a protective immune response in about 10% of vaccinees. DNA vaccination and the inclusion of PreS1 and PreS2 domains of HBsAg have been reported to represent feasible...

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Detalhes bibliográficos
Main Authors: Endmann, Anne, Klünder, Katharina, Kapp, Kerstin, Riede, Oliver, Oswald, Detlef, Talman, Eduard G., Schroff, Matthias, Kleuss, Christiane, Ruiters, Marcel H. J., Juhls, Christiane
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081723/
https://ncbi.nlm.nih.gov/pubmed/24992038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101715
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