Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.

Growth inhibition assays indicated that the IC50 values for methotrexate (MTX) and 5-fluorodeoxyuridine (FdUrd) in HS-18, a liposarcoma cell line lacking retinoblastoma protein (pRB), and SaOS-2, an osteosarcoma cell line with a truncated and nonfunctional pRB, were 10- to 12-fold and 4- to 11-fold...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Li, W, Fan, J, Hochhauser, D, Banerjee, D, Zielinski, Z, Almasan, A, Yin, Y, Kelly, R, Wahl, G M, Bertino, J R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479800/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.22.10436
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