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PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor
BACKGROUND AND PURPOSE: The μ-opioid receptor has been characterized as the main mediator of opioid signalling in neuronal cells. Opioid-induced pain suppression was originally proposed to be mediated by μ-opioid receptor-induced inhibitory effects on cAMP, which is known to mediate inflammatory hyp...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4080984/ https://ncbi.nlm.nih.gov/pubmed/24654606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12698 |
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