Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

BACKGROUND AND PURPOSE: Recent clinical trials report that metformin, an activator of AMP-activated protein kinase (AMPK) used to treat type 2 diabetes, significantly reduces the risk of stroke by actions that are independent of its glucose-lowering effects. However, the underlying molecular mechani...

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Autors principals: Jiang, Teng, Yu, Jin-Tai, Zhu, Xi-Chen, Wang, Hui-Fu, Tan, Meng-Shan, Cao, Lei, Zhang, Qiao-Quan, Gao, Li, Shi, Jian-Quan, Zhang, Ying-Dong, Tan, Lan
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2014
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080970/
https://ncbi.nlm.nih.gov/pubmed/24611741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12655
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