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Feedback circuits monitor and adjust basal Lck-dependent events in T cell antigen receptor signaling

The Src family kinase Lck is crucial for initiation of T cell antigen receptor (TCR) signaling. Lck is tightly controlled to prevent erroneous immune activation, yet allows rapid responses over a range of sensitivities to antigens. Here, using an analog-sensitive Csk we report that Lck is dynamicall...

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Detalhes bibliográficos
Main Authors: Schoenborn, Jamie R., Tan, Ying Xim, Zhang, Cha o, Shokat, Kevan M., Weiss, Arthur
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080844/
https://ncbi.nlm.nih.gov/pubmed/21917715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001893
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