Capillary nano-immunoassay for Akt 1/2/3 and 4EBP1 phosphorylation in acute myeloid leukemia

BACKGROUND: Overall cure rates in acute myeloid leukemia (AML) continue to range between 60-65% with disease relapse being a major cause of mortality. The PI3K-Akt-mTOR kinase pathway plays a vital role in pro-survival signals within leukemic cells and inhibition of this pathway is being investigate...

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Hlavní autoři: Sabnis, Himalee, Bradley, Heath L, Bunting, Silvia T, Cooper, Todd M, Bunting, Kevin D
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Methodology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080754/
https://ncbi.nlm.nih.gov/pubmed/24923301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-12-166
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