Combination of secretin and fluvastatin ameliorates the polyuria associated with X-linked nephrogenic diabetes insipidus in mice

X-linked nephrogenic diabetes insipidus (X-NDI) is a disease caused by inactivating mutations of the vasopressin (AVP) type 2 receptor (V2R) gene. Loss of V2R function prevents plasma membrane expression of the AQP2 water channel in the kidney collecting duct cells and impairs the kidney concentrati...

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Detalhes bibliográficos
Main Authors: Procino, Giuseppe, Milano, Serena, Carmosino, Monica, Barbieri, Claudia, Nicoletti, Maria C, H. Li, Jian, Wess, Jürgen, Svelto, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080339/
https://ncbi.nlm.nih.gov/pubmed/24522493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2014.10
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