Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway

BACKGROUND: Macrophage infiltration to inflammatory sites promotes wound repair and may be involved in pain hypersensitivity after surgical incision. We recently reported that the development of hyperalgesia during chronic inflammation is regulated by macrophage polarity, often referred to as proinf...

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Bibliographic Details
Main Authors: Godai, Kohei, Hasegawa-Moriyama, Maiko, Kurimoto, Tae, Saito, Takayuki, Yamada, Tomotsugu, Sato, Takahiro, Kojima, Masayasu, Kanmura, Yuichi
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079829/
https://ncbi.nlm.nih.gov/pubmed/24928142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-10-36
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