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Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway

BACKGROUND: Macrophage infiltration to inflammatory sites promotes wound repair and may be involved in pain hypersensitivity after surgical incision. We recently reported that the development of hyperalgesia during chronic inflammation is regulated by macrophage polarity, often referred to as proinf...

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Detalhes bibliográficos
Main Authors: Godai, Kohei, Hasegawa-Moriyama, Maiko, Kurimoto, Tae, Saito, Takayuki, Yamada, Tomotsugu, Sato, Takahiro, Kojima, Masayasu, Kanmura, Yuichi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079829/
https://ncbi.nlm.nih.gov/pubmed/24928142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-10-36
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