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The Transcription Factor MEF2C Negatively Controls Angiogenic Sprouting of Endothelial Cells Depending on Oxygen

The MADS box transcription factor MEF2C has been detected by us to be upregulated by the angiogenic factors VEGF-A and bFGF in endothelial cells. We have here investigated its potential role for angiogenesis. MEF2C was surprisingly found to strongly inhibit angiogenic sprouting, whereas a dominant n...

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Autors principals: Sturtzel, Caterina, Testori, Julia, Schweighofer, Bernhard, Bilban, Martin, Hofer, Erhard
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079651/
https://ncbi.nlm.nih.gov/pubmed/24988463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101521
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