CXC Chemokine Ligand 12 Protects Pancreatic β-Cells from Necrosis through Akt Kinase-Mediated Modulation of Poly(ADP-ribose) Polymerase-1 Activity

The diabetes prevention paradigm envisages the application of strategies that support the maintenance of appropriate β-cell numbers. Herein we show that overexpression of CXC chemokine ligand12 (CXCL12) considerably improves the viability of isolated rat Langerhans islet cells and Rin-5F pancreatic...

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Hauptverfasser: Grdović, Nevena, Dinić, Svetlana, Mihailović, Mirjana, Uskoković, Aleksandra, Jovanović, Jelena Arambašić, Poznanović, Goran, Wagner, Ludwig, Vidaković, Melita
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079329/
https://ncbi.nlm.nih.gov/pubmed/24988468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101172
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