A Phase 1 Trial of Imetelstat in Children with Refractory or Recurrent Solid Tumors: A Children’s Oncology Group Phase 1 Consortium Study (ADVL1112)

PURPOSE: Imetelstat is a covalently-lipidated 13-mer thiophosphoramidate oligonucleotide that acts as a potent specific inhibitor of telomerase. It binds with high affinity to the template region of the RNA component of human telomerase (hTERC ) and is a competitive inhibitor of telomerase enzymatic...

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Autori principali: Thompson, Patrick A., Drissi, Rachid, Muscal, Jodi A., Panditharatna, Eshini, Fouladi, Maryam, Ingle, Ashish M., Ahern, Charlotte H., Reid, Joel M., Lin, Tong, Weigel, Brenda J., Blaney, Susan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079262/
https://ncbi.nlm.nih.gov/pubmed/24097866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1117
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