Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke

BACKGROUND AND PURPOSE: The role of autophagy in response to ischemic stroke has been confusing with reports that both enhancement and inhibition of autophagy decrease infarct size and improve post-stroke outcomes. We sought to clarify this by comparing pharmacologic modulation of autophagy in two c...

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Detalhes bibliográficos
Main Authors: Buckley, Kathleen M, Hess, Daniel L, Sazonova, Irina Y, Periyasamy-Thandavan, Sudharsan, Barrett, John R, Kirks, Russell, Grace, Harrison, Kondrikova, Galina, Johnson, Maribeth H, Hess, David C, Schoenlein, Patricia V, Hoda, Md Nasrul, Hill, William D
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079187/
https://ncbi.nlm.nih.gov/pubmed/24991402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-7378-6-8
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