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A fabricated siRNA nanoparticle for ultra-long gene silencing in vivo
Persistent gene silencing is crucially required for the successful therapeutics of short interfering RNA (siRNA). Here, we describe a nanoparticle based delivery system which assembled by layering siRNAs between protease degradable polypeptides to extend the therapeutic window. These tightly packed...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4078887/ https://ncbi.nlm.nih.gov/pubmed/24999314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adfm.201202777 |
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