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A role for Drosophila ATX2 in activation of PER translation and circadian behavior
A negative transcriptional feedback loop generates circadian rhythms in Drosophila. PERIOD (PER) is a critical state-variable in this mechanism, and its abundance is tightly regulated. We found that the Drosophila homolog of Ataxin-2 (ATX2) – an RNA binding protein implicated in human neurodegenerat...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4078874/ https://ncbi.nlm.nih.gov/pubmed/23687048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1234746 |
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