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Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation

The molecular mechanisms underlying atrial fibrillation, the most common sustained cardiac arrhythmia, remain poorly understood. Genome-wide association studies uncovered a major atrial fibrillation susceptibility locus on human chromosome 4q25 in close proximity to the paired-like homeodomain trans...

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Hlavní autoři: Wang, Jun, Bai, Yan, Li, Na, Ye, Wenduo, Zhang, Min, Greene, Stephanie B., Tao, Ye, Chen, Yiping, Wehrens, Xander H. T., Martin, James F.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078868/
https://ncbi.nlm.nih.gov/pubmed/24927531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405411111
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