Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity

The best-understood mechanisms for achieving antibody self/non-self discrimination discard self-reactive antibodies before they can be tested for binding microbial antigens, potentially creating holes in the repertoire. Here we provide evidence for a complementary mechanism: retaining autoantibodies...

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Bibliografske podrobnosti
Main Authors: Sabouri, Zahra, Schofield, Peter, Horikawa, Keisuke, Spierings, Emily, Kipling, David, Randall, Katrina L., Langley, David, Roome, Brendan, Vazquez-Lombardi, Rodrigo, Rouet, Romain, Hermes, Jana, Chan, Tyani D., Brink, Robert, Dunn-Walters, Deborah K., Christ, Daniel, Goodnow, Christopher C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078846/
https://ncbi.nlm.nih.gov/pubmed/24821781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406974111
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