Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer

The transcription factor c-MYC is stabilized and activated by phosphorylation at serine 62 (S62) in breast cancer. Protein phosphatase 2A (PP2A) is a critical negative regulator of c-MYC through its ability to dephosphorylate S62. By inactivating c-MYC and other key signaling pathways, PP2A plays an...

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Main Authors: Janghorban, Mahnaz, Farrell, Amy S., Allen-Petersen, Brittany L., Pelz, Carl, Daniel, Colin J., Oddo, Jessica, Langer, Ellen M., Christensen, Dale J., Sears, Rosalie C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078832/
https://ncbi.nlm.nih.gov/pubmed/24927563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317630111
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