טוען...
Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer
The transcription factor c-MYC is stabilized and activated by phosphorylation at serine 62 (S62) in breast cancer. Protein phosphatase 2A (PP2A) is a critical negative regulator of c-MYC through its ability to dephosphorylate S62. By inactivating c-MYC and other key signaling pathways, PP2A plays an...
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Main Authors: | , , , , , , , , |
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פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
National Academy of Sciences
2014
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4078832/ https://ncbi.nlm.nih.gov/pubmed/24927563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317630111 |
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