Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens

Understanding the mechanisms by which compounds discovered using cell-based phenotypic screening strategies might exert their effects would be highly augmented by new approaches exploring their potential interactions with the genome. For example, altered androgen receptor (AR) transcriptional progra...

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Detalhes bibliográficos
Main Authors: Jin, Chunyu, Yang, Liuqing, Xie, Min, Lin, Chunru, Merkurjev, Daria, Yang, Joy C., Tanasa, Bogdan, Oh, Soohwan, Zhang, Jie, Ohgi, Kenneth A., Zhou, Hongyan, Li, Wenbo, Evans, Christopher P., Ding, Sheng, Rosenfeld, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078819/
https://ncbi.nlm.nih.gov/pubmed/24928520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404303111
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