Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis

Monocyte chemoattractant protein-1 (MCP-1) is upregulated in renal parenchymal cells during kidney disease. To investigate whether MCP-1 promotes tubular and/or glomerular injury, we induced nephrotoxic serum nephritis (NSN) in MCP-1 genetically deficient mice. Mice were analyzed when tubules and gl...

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Main Authors: Tesch, Gregory H., Schwarting, Andreas, Kinoshita, Koji, Lan, Hui Y., Rollins, Barrett J., Kelley, Vicki Rubin
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1999
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC407867/
https://ncbi.nlm.nih.gov/pubmed/9884336
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