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A genomic selection strategy to identify accessible and dimerization blocking targets in the 5′-UTR of HIV-1 RNA
Defining target sites for antisense oligonucleotides in highly structured RNA is a non-trivial exercise that has received much attention. Here we describe a novel and simple method to generate a library composed of all 20mer oligoribonucleotides that are sense- and antisense to any given sequence or...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC407842/ https://ncbi.nlm.nih.gov/pubmed/15107482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnh064 |
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