A novel technique based on a PNA hybridization probe and FRET principle for quantification of mutant genotype in fibrous dysplasia/McCune–Albright syndrome

Somatic mutations are present in various proportions in numerous developmental pathologies. Somatic activating missense mutations of the GNAS gene encoding the Gs(α) protein have previously been shown to be the cause of fibrous dysplasia of bone (FD)/McCune-Albright syndrome (MAS). Because in MAS pa...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Karadag, Abdullah, Riminucci, Mara, Bianco, Paolo, Cherman, Natasha, Kuznetsov, Sergei A., Nguyen, Nga, Collins, Michael T., Robey, Pamela G., Fisher, Larry W.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2004
Sujets:
NAR Methods Online
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC407839/
https://ncbi.nlm.nih.gov/pubmed/15096559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnh059
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