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Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development

BACKGROUND: Striking a balance between the degree of model complexity and parameter identifiability, while still producing biologically feasible simulations using modelling is a major challenge in computational biology. While these two elements of model development are closely coupled, parameter fit...

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Autori principali: Tøndel, Kristin, Niederer, Steven A, Land, Sander, Smith, Nicolas P
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078362/
https://ncbi.nlm.nih.gov/pubmed/24886522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-8-59
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