The spin trap 5,5-dimethyl-1-pyrroline N-oxide inhibits lipopolysaccharide-induced inflammatory response in RAW 264.7 cells

AIM: Exposure of macrophages to lipopolysaccharide (LPS) induces oxidative and inflammatory stresses, which cause cell damage. Antioxidant and anti-inflammatory properties have been attributed to the nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO), commonly used in free radical analysis, b...

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Bibliographic Details
Main Authors: Zhai, Zili, Gomez-Mejiba, Sandra E., Zhu, Hua, Lupu, Florea, Ramirez, Dario C.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078025/
https://ncbi.nlm.nih.gov/pubmed/22285597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2011.12.018
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