Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice

Aldehyde dehydrogenase 2 (ALDH2) is the major enzyme that metabolizes acetaldehyde produced from alcohol metabolism. Approximately 40~50% of East Asians carry an inactive ALDH2 gene and exhibit acetaldehyde accumulation after alcohol consumption. However, the role of ALDH2 deficiency in the pathogen...

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Hauptverfasser: Kwon, Hyo-Jung, Won, Young-Suk, Park, Ogyi, Chang, Binxia, Duryee, Michael J., Thiele, Geoffrey E., Matsumoto, Akiko, Singh, Surendra, Abdelmegeed, Mohamed A., Song, Byoung-Joon, Kawamoto, Toshihiro, Vasiliou, Vasilis, Thiele, Geoffrey M., Gao, Bin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077916/
https://ncbi.nlm.nih.gov/pubmed/24492981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27036
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