Alum and Squalene-Oil-in-Water Emulsion Enhance the Titer and Avidity of Anti-Aβ Antibodies Induced by Multimeric Protein Antigen (1–11)E2, Preserving the Igg1-Skewed Isotype Distribution

The development of active immunotherapy for Alzheimer's disease (AD) requires the identification of immunogens that can ensure a high titer antibody response toward Aβ, while minimizing the risks of adverse reactions. Multimeric protein (1–11)E2 induces a robust and persistent antibody response...

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Detalhes bibliográficos
Main Authors: Mantile, Francesca, Trovato, Maria, Santoni, Andrea, Barba, Pasquale, Ottonello, Simone, De Berardinis, Piergiuseppe, Prisco, Antonella
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077797/
https://ncbi.nlm.nih.gov/pubmed/24983378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101474
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