Biomimetic High Density Lipoprotein Nanoparticles For Nucleic Acid Delivery

We report a gold nanoparticle-templated high density lipoprotein (HDL AuNP) platform for gene therapy which combines lipid-based nucleic acid transfection strategies with HDL biomimicry. For proof-of-concept, HDL AuNPs are shown to adsorb antisense cholesterylated DNA. The conjugates are internalize...

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Detalhes bibliográficos
Main Authors: McMahon, Kaylin M., Mutharasan, R. Kannan, Tripathy, Sushant, Veliceasa, Dorina, Bobeica, Mariana, Shumaker, Dale K., Luthi, Andrea J., Helfand, Brian T., Ardehali, Hossein, Mirkin, Chad A., Volpert, Olga, Thaxton, C. Shad
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077779/
https://ncbi.nlm.nih.gov/pubmed/21319839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nl1041947
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