Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors(1–3). Recent screening studies have begun to catalogue ISGs with antiviral activity against several RNA and DNA viruses...

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Detalhes bibliográficos
Main Authors: Schoggins, John W., MacDuff, Donna A., Imanaka, Naoko, Gainey, Maria D., Shrestha, Bimmi, Eitson, Jennifer L., Mar, Katrina B., Richardson, R. Blake, Ratushny, Alexander V., Litvak, Vladimir, Dabelic, Rea, Manicassamy, Balaji, Aitchison, John D., Aderem, Alan, Elliott, Richard M., García-Sastre, Adolfo, Racaniello, Vincent, Snijder, Eric J., Yokoyama, Wayne M., Diamond, Michael S., Virgin, Herbert W., Rice, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077721/
https://ncbi.nlm.nih.gov/pubmed/24284630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12862
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