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Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives

An efficient Ugi three-component reaction of a preformed chiral ketimine derived from isatin with various isonitrile and acid components has been developed. The reactions proceeded smoothly and in a stereocontrolled manner with regard to the new center of the Ugi products due to the stereoinduction...

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Main Authors: Lesma, Giordano, Meneghetti, Fiorella, Sacchetti, Alessandro, Stucchi, Mattia, Silvani, Alessandra
Format: Artigo
Jezik:Inglês
Izdano: Beilstein-Institut 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077467/
https://ncbi.nlm.nih.gov/pubmed/24991292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.10.141
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