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MicroRNA-133a regulates DNA methylation in diabetic cardiomyocytes
We tested the hypothesis that miR-133a regulates DNA methylation by inhibiting Dnmt-1 (maintenance) and Dnmt-3a and -3b (de novo) methyl transferase in diabetic hearts by using Ins2+/− Akita (diabetic) and C57BL/6J (WT) mice and HL1 cardiomyocytes. The specific role of miR-133a in DNA methylation in...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4077351/ https://ncbi.nlm.nih.gov/pubmed/22842467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.07.105 |
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