The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.

Recent experimental evidence has focused attention to the role of two molecules, insulin receptor substrate 1 (IRS-1) and phosphatidylinositol 3-kinase (PI3-kinase), in linking the insulin receptor to glucose uptake; IRS-1 knockout mice are insulin resistant, and pharmacological inhibitors of PI3-ki...

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Detaylı Bibliyografya
Asıl Yazarlar: Isakoff, S J, Taha, C, Rose, E, Marcusohn, J, Klip, A, Skolnik, E Y
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1995
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC40773/
https://ncbi.nlm.nih.gov/pubmed/7479761
Etiketler: Etiketle
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