Thiazolidione derivatives targeting the histidine kinase YycG are effective against both planktonic and biofilm-associated Staphylococcus epidermidis

AIM: To evaluate the efficacies of six derivatives of Compound 2, a novel YycG histidine kinase inhibitor with the thiazolidione core structure in the treatment of medical device-related biofilm infections. METHODS: The minimal inhibitory concentration (MIC) of the derivatives was determined using t...

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Detalhes bibliográficos
Main Authors: Huang, Ren-zheng, Zheng, Li-kang, Liu, Hua-yong, Pan, Bin, Hu, Jian, Zhu, Tao, Wang, Wei, Jiang, Dan-bin, Wu, Yang, Wu, You-cong, Han, Shi-qing, Qu, Di
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077129/
https://ncbi.nlm.nih.gov/pubmed/22231397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.166
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