A novel self-lipid antigen targets human T cells against CD1c(+) leukemias

T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects. We report that CD1c self-reactive T cells recognize a nov...

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Auteurs principaux: Lepore, Marco, de Lalla, Claudia, Gundimeda, S. Ramanjaneyulu, Gsellinger, Heiko, Consonni, Michela, Garavaglia, Claudio, Sansano, Sebastiano, Piccolo, Francesco, Scelfo, Andrea, Häussinger, Daniel, Montagna, Daniela, Locatelli, Franco, Bonini, Chiara, Bondanza, Attilio, Forcina, Alessandra, Li, Zhiyuan, Ni, Guanghui, Ciceri, Fabio, Jenö, Paul, Xia, Chengfeng, Mori, Lucia, Dellabona, Paolo, Casorati, Giulia, De Libero, Gennaro
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076585/
https://ncbi.nlm.nih.gov/pubmed/24935257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140410
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