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Loss of Smad4 in Sertoli and Leydig Cells Leads to Testicular Dysgenesis and Hemorrhagic Tumor Formation in Mice

As the central component of canonical TGFbeta superfamily signaling, SMAD4 is a critical regulator of organ development, patterning, tumorigenesis, and many other biological processes. Because numerous TGFbeta superfamily ligands are expressed in developing testes, there may exist specific requireme...

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Detalhes bibliográficos
Main Authors: Archambeault, Denise R., Yao, Humphrey Hung-Chang
Formato: Artigo
Idioma:Inglês
Publicado em: Society for the Study of Reproduction, Inc. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076392/
https://ncbi.nlm.nih.gov/pubmed/24501173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.113.111393
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