PPARδ activation attenuates hepatic steatosis in Ldlr(−/−) mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

PPARδ regulates systemic lipid homeostasis and inflammation, but its role in hepatic lipid metabolism remains unclear. Here, we examine whether intervening with a selective PPARδ agonist corrects hepatic steatosis induced by a high-fat, cholesterol-containing (HFHC) diet. Ldlr(−/−) mice were fed a c...

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Détails bibliographiques
Auteurs principaux: Bojic, Lazar A., Telford, Dawn E., Fullerton, Morgan D., Ford, Rebecca J., Sutherland, Brian G., Edwards, Jane Y., Sawyez, Cynthia G., Gros, Robert, Kemp, Bruce E., Steinberg, Gregory R., Huff, Murray W.
Format: Artigo
Langue:Inglês
Publié: The American Society for Biochemistry and Molecular Biology 2014
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076091/
https://ncbi.nlm.nih.gov/pubmed/24864274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M046037
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