PPARδ activation attenuates hepatic steatosis in Ldlr(−/−) mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

PPARδ regulates systemic lipid homeostasis and inflammation, but its role in hepatic lipid metabolism remains unclear. Here, we examine whether intervening with a selective PPARδ agonist corrects hepatic steatosis induced by a high-fat, cholesterol-containing (HFHC) diet. Ldlr(−/−) mice were fed a c...

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Hlavní autoři: Bojic, Lazar A., Telford, Dawn E., Fullerton, Morgan D., Ford, Rebecca J., Sutherland, Brian G., Edwards, Jane Y., Sawyez, Cynthia G., Gros, Robert, Kemp, Bruce E., Steinberg, Gregory R., Huff, Murray W.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2014
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076091/
https://ncbi.nlm.nih.gov/pubmed/24864274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M046037
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