Population pharmacokinetics and pharmacodynamics of bivalirudin in young healthy Chinese volunteers

AIM: To investigate the population pharmacokinetics (PK) and pharmacodynamics (PD) of bivalirudin, a synthetic bivalent direct thrombin inhibitor, in young healthy Chinese subjects. METHODS: Thirty-six young healthy volunteers were randomly assigned into 4 groups received bivalirudin 0.5 mg/kg, 0.75...

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Hlavní autoři: Zhang, Dong-mei, Wang, Kun, Zhao, Xia, Li, Yun-fei, Zheng, Qing-shan, Wang, Zi-ning, Cui, Yi-min
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076004/
https://ncbi.nlm.nih.gov/pubmed/22659624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.37
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