Molecular Basis of Pirh2-mediated p53 Ubiquitylation

Pirh2 (p53-induced RING-H2 domain protein, also known as Rchy1), is an E3 ubiquitin ligase involved in a negative-feedback loop with p53. Using NMR spectroscopy we show that Pirh2 is a unique cysteine-rich protein comprising three modular domains. The protein binds nine zinc ions using a variety of...

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Detalhes bibliográficos
Main Authors: Sheng, Yi, Laister, Rob, Lemak, Alexander, Wu, Bin, Tai, Elizabeth, Duan, Shili, Lukin, Jonathan, Sunnerhagen, Maria, Srisailam, Sampath, Karra, Murthy, Benchimol, Sam, Arrowsmith, Cheryl H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075976/
https://ncbi.nlm.nih.gov/pubmed/19043414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1521
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