Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition

BACKGROUND: Disulfiram (DS), an anti-alcoholism drug, demonstrates strong antitumor activity in a copper (Cu)-dependent manner. This study investigates the cytotoxicity of DS/Cu complex in lymphoid malignant cell lines in vitro and in vivo. METHOD: Raji cells were subjected to different treatments a...

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Detalhes bibliográficos
Main Authors: Zha, Jie, Chen, Feili, Dong, Huijuan, Shi, Pengcheng, Yao, Yao, Zhang, Yanyan, Li, Rongwei, Wang, Shiyun, Li, Peng, Wang, Weiguang, Xu, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075939/
https://ncbi.nlm.nih.gov/pubmed/24915933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-12-163
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