Doxycycline use in patients with lymphangioleiomyomatosis: biomarkers and pulmonary function response ,

OBJECTIVE: To assess blockade of matrix metalloproteinase (MMP)-2 and MMP-9, as well as the variation in FEV(1), in patients with lymphangioleiomyomatosis (LAM) treated with doxycycline (a known MMP inhibitor) for 12 months. METHODS: An open-label, single-arm, interventional clinical trial in which...

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Autors principals: Pimenta, Suzana Pinheiro, Baldi, Bruno Guedes, Kairalla, Ronaldo Adib, Carvalho, Carlos Roberto Ribeiro
Format: Artigo
Idioma:Inglês
Publicat: Sociedade Brasileira de Pneumologia e Tisiologia 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075801/
https://ncbi.nlm.nih.gov/pubmed/23503480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/S1806-37132013000100002
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