Mucosal SIV Vaccines Comprising Inactivated Virus Particles and Bacterial Adjuvants Induce CD8(+) T-Regulatory Cells that Suppress SIV-Positive CD4(+) T-Cell Activation and Prevent SIV Infection in the Macaque Model

A new paradigm of mucosal vaccination against human immunodeficiency virus (HIV) infection has been investigated in the macaque model. A vaccine consisting of inactivated simian immunodeficiency virus (SIV)mac239 particles together with a living bacterial adjuvant (either the Calmette and Guerin bac...

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Bibliografiska uppgifter
Huvudupphovsmän: Andrieu, Jean-Marie, Chen, Song, Lai, Chunhui, Guo, Weizhong, Lu, Wei
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2014
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074992/
https://ncbi.nlm.nih.gov/pubmed/25071760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00297
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