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The Src homology-2 protein Shb modulates focal adhesion kinase signaling in a BCR-ABL myeloproliferative disorder causing accelerated progression of disease

BACKGROUND: The Src homology-2 domain protein B (Shb) is an adapter protein operating downstream of several tyrosine kinase receptors and consequently Shb regulates various cellular responses. Absence of Shb was recently shown to reduce hematopoietic stem cell proliferation through activation of foc...

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מידע ביבליוגרפי
Main Authors: Gustafsson, Karin, Jamalpour, Maria, Trinh, Camilla, Kharas, Michael G, Welsh, Michael
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074852/
https://ncbi.nlm.nih.gov/pubmed/24952416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-7-45
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