Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer

BACKGROUND: The outcome of patients with metastatic colorectal carcinoma (mCRC) following first line therapy is poor, with median survival of less than one year. The purpose of this study was to identify candidate therapeutically targetable somatic events in mCRC patient samples by whole genome sequ...

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Detalhes bibliográficos
Main Authors: Shanmugam, Vijayalakshmi, Ramanathan, Ramesh K, Lavender, Nicole A, Sinari, Shripad, Chadha, Manpreet, Liang, Winnie S, Kurdoglu, Ahmet, Izatt, Tyler, Christoforides, Alexis, Benson, Hollie, Phillips, Lori, Baker, Angela, Murray, Christopher, Hostetter, Galen, Von Hoff, Daniel D, Craig, David W, Carpten, John D
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074842/
https://ncbi.nlm.nih.gov/pubmed/24943349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-7-36
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