Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer

BACKGROUND: The outcome of patients with metastatic colorectal carcinoma (mCRC) following first line therapy is poor, with median survival of less than one year. The purpose of this study was to identify candidate therapeutically targetable somatic events in mCRC patient samples by whole genome sequ...

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Hlavní autoři: Shanmugam, Vijayalakshmi, Ramanathan, Ramesh K, Lavender, Nicole A, Sinari, Shripad, Chadha, Manpreet, Liang, Winnie S, Kurdoglu, Ahmet, Izatt, Tyler, Christoforides, Alexis, Benson, Hollie, Phillips, Lori, Baker, Angela, Murray, Christopher, Hostetter, Galen, Von Hoff, Daniel D, Craig, David W, Carpten, John D
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074842/
https://ncbi.nlm.nih.gov/pubmed/24943349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-7-36
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