Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer

BACKGROUND: The outcome of patients with metastatic colorectal carcinoma (mCRC) following first line therapy is poor, with median survival of less than one year. The purpose of this study was to identify candidate therapeutically targetable somatic events in mCRC patient samples by whole genome sequ...

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Bibliografiske detaljer
Main Authors: Shanmugam, Vijayalakshmi, Ramanathan, Ramesh K, Lavender, Nicole A, Sinari, Shripad, Chadha, Manpreet, Liang, Winnie S, Kurdoglu, Ahmet, Izatt, Tyler, Christoforides, Alexis, Benson, Hollie, Phillips, Lori, Baker, Angela, Murray, Christopher, Hostetter, Galen, Von Hoff, Daniel D, Craig, David W, Carpten, John D
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074842/
https://ncbi.nlm.nih.gov/pubmed/24943349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-7-36
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